Differential MHC-II expression and phagocytic functions of embryo-derived cardiac macrophages in the course of myocardial infarction in mice

Eur J Immunol. 2021 Jan;51(1):250-252. doi: 10.1002/eji.202048560. Epub 2020 Aug 27.

Abstract

In mouse myocardial infarction, we combined lineage tracing of cardiac macrophages, mapping their ontogeny, with an analysis of their phenotype and phagocytic functions. While embryo-derived macrophages were most abundant in homeostasis, bone marrow-derived MHC-IIlo macrophages increased in both numbers and phagocytic capacity to clear necrotic cardiomyocytes early after ischemia/perfusion injury.

Keywords: CCR2; MHC-II; embryo; macrophages; myocardial infarction; phagocytosis.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • CX3C Chemokine Receptor 1 / metabolism
  • Disease Models, Animal
  • Embryo, Mammalian / cytology
  • Embryo, Mammalian / immunology
  • Histocompatibility Antigens Class II / metabolism*
  • Macrophages / immunology*
  • Macrophages / pathology
  • Mice
  • Mice, Transgenic
  • Myocardial Infarction / immunology*
  • Myocardial Infarction / pathology
  • Myocardium / immunology*
  • Myocardium / pathology
  • Myocytes, Cardiac / immunology
  • Myocytes, Cardiac / pathology
  • Phagocytosis / immunology

Substances

  • CX3C Chemokine Receptor 1
  • Cx3cr1 protein, mouse
  • Histocompatibility Antigens Class II