Acinic cell carcinoma of the salivary gland associated with lymphoid-rich stroma. A diagnostic dilemma on cytology: Study of two cases

Diagn Cytopathol. 2021 Feb;49(2):E55-E59. doi: 10.1002/dc.24571. Epub 2020 Aug 6.

Abstract

A lymphoid-rich stroma is a common finding in salivary gland tumors. Several reports documented this association with acinic cell carcinoma (ACC). However, cytologic studies reporting this phenomenon are rare and mainly confined to sporadic single case reports. We present the cytologic features of two cases of ACCs of the parotid gland displaying a lymphoid-rich background and discuss the cytologic differential diagnoses of this uncommon ACC variant.

Keywords: acinic cell carcinoma; lymphoid-rich stroma cytology; salivary gland cytology.

Publication types

  • Case Reports

MeSH terms

  • Biopsy, Needle / methods
  • Carcinoma, Acinar Cell / diagnosis*
  • Carcinoma, Acinar Cell / pathology*
  • Cytodiagnosis / methods
  • Cytological Techniques / methods
  • Diagnosis, Differential
  • Female
  • Humans
  • Lymphocytes / pathology*
  • Middle Aged
  • Parotid Gland / pathology
  • Parotid Neoplasms / diagnosis
  • Parotid Neoplasms / pathology
  • Salivary Gland Neoplasms / diagnosis*
  • Salivary Gland Neoplasms / pathology*
  • Salivary Glands / pathology