Primary Melanoma of the Lung Treated with Surgery, Dabrafenib and Trametinib

Case Rep Oncol. 2020 Jul 7;13(2):789-792. doi: 10.1159/000508093. eCollection 2020 May-Aug.

Abstract

This is a case report on a 69-year-old woman who was diagnosed with malignant melanoma presenting in the lung. A complete staging workup was performed by her oncologist, with no skin lesion identified as a primary. CT-guided needle biopsy of the lung nodule was completed, with pathology revealing atypical cells consistent with malignant melanoma. Following full body examination by the cutaneous oncologist, a robotic wedge resection and lymph node dissection accompanied by bronchoscopy were performed. Molecular testing (Caris Life Sciences) of the surgical tumor specimen revealed pathological BRAF DNA mutation in exon 15/p.V600K. The patient was initially treated with nivolumab, then treated with a combination of dabrafenib and trametinib at recurrence.

Keywords: BRAF mutation V600K; Primary lung melanoma; Pulmonary melanoma.

Publication types

  • Case Reports