Can potential hazard of Creutzfeldt-Jakob disease infectivity be reduced in the production of human growth hormone? Inactivation experiments with the 263K strain of scrapie. Rapid communication

M Pocchiari; G Macchi; S Peano; A Conz

doi:10.1007/BF01321014

Can potential hazard of Creutzfeldt-Jakob disease infectivity be reduced in the production of human growth hormone? Inactivation experiments with the 263K strain of scrapie. Rapid communication

Arch Virol. 1988;98(1-2):131-5. doi: 10.1007/BF01321014.

Authors

M Pocchiari¹, G Macchi, S Peano, A Conz

Affiliation

¹ Istituto di Neurologia, Universitá Cattolica S. Cuore, Rome, Italy.

PMID: 3277594
DOI: 10.1007/BF01321014

Abstract

Scrapie infectivity is reduced 5-6 logs following filtration through 100,000 MW cut-off filter plus overnight treatment with 6 M urea. These steps, applied to purified human Growth Hormone (hGH), increase the margin of safety of hGH.

MeSH terms

Animals
Creutzfeldt-Jakob Syndrome / prevention & control*
Cricetinae
Female
Filtration
Growth Hormone / isolation & purification*
Scrapie / prevention & control*
Sodium Hydroxide
Urea

Substances

Sodium Hydroxide
Urea
Growth Hormone