Comparison of MOG and AQP4 antibody seroprevalence in Korean adults with inflammatory demyelinating CNS diseases

Mult Scler. 2021 May;27(6):964-967. doi: 10.1177/1352458520948213. Epub 2020 Aug 11.

Abstract

We aimed to compare seroprevalence of anti-myelin oligodendrocyte glycoprotein (MOG) and anti-aquaporin-4 (AQP4) antibodies in Korean adults with inflammatory demyelinating diseases (IDDs) of the central nervous system (CNS), based on a multicenter nationwide database. Sera were analyzed using a live cell-based assay for MOG and AQP4 antibodies. Of 586 Korean adults with IDDs of the CNS, 36 (6.1%) and 185 (31.6%) tested positive for MOG and AQP4 antibodies, respectively. No participant showed double positivity. Seroprevalence of MOG antibodies was about five times lower than that of AQP4 antibodies in a large cohort of Korean adults with IDDs of the CNS.

Keywords: Aquaporin-4; adult; myelin oligodendrocyte glycoprotein; prevalence.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aquaporin 4*
  • Central Nervous System Diseases*
  • Humans
  • Myelin-Oligodendrocyte Glycoprotein
  • Republic of Korea / epidemiology
  • Seroepidemiologic Studies

Substances

  • Aquaporin 4
  • Myelin-Oligodendrocyte Glycoprotein