Antiproliferative activity of a new xanthone derivative from leaves of Garcinia nobilis Engl

Nat Prod Res. 2021 Dec;35(24):5604-5611. doi: 10.1080/14786419.2020.1806270. Epub 2020 Aug 13.

Abstract

A new xanthone, mboudiexanthone (1), together with five known compounds, euxanthone (2), isogarcinol (3), garcinol (4), betulinic acid (5) and zeorin (6) were isolated from the leaves of Garcinia nobilis Engl. The structures were determined by 1D and 2D NMR techniques and X-ray diffraction for 6. The in vitro antiproliferative properties of isolated compounds were evaluated against the human breast cancer cell line MCF-7. All compounds showed an antiproliferative activity with an IC50 value down to ∼11 µM for isogarcinol.

Keywords: Garcinia nobilis Engl.; Guttiferae; antiproliferative activity; xanthone.

MeSH terms

  • Garcinia*
  • Humans
  • Molecular Structure
  • Plant Extracts / pharmacology
  • Plant Leaves
  • Xanthones* / pharmacology

Substances

  • Plant Extracts
  • Xanthones