A hairy tale: SIRT7 safeguards skin stem cells during aging

EMBO J. 2020 Sep 15;39(18):e106294. doi: 10.15252/embj.2020106294. Epub 2020 Aug 16.

Abstract

Stem cell regulation during both normal development and aging has become one of the fastest growing topics in biology. Here, new work by Li et al (2020) offers insight into the aging process within epithelial skin stem cells and highlights how SIRT7, a member of the sirtuin family of protein deacylases and mono-ADP ribosylases, protects adult hair follicle stem cells from aging by ensuring their hair cycle progression.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Aging / genetics
  • Animals
  • Hair Follicle*
  • Mice
  • Sirtuins* / genetics
  • Skin Physiological Phenomena
  • Stem Cells

Substances

  • Sirt7 protein, mouse
  • Sirtuins