Invasive Disease Potential of Pneumococcal Serotypes in Children After PCV13 Implementation

Robert Cohen; Corinne Levy; Naim Ouldali; Marie Goldrey; Stéphane Béchet; Stéphane Bonacorsi; Emmanuelle Varon

doi:10.1093/cid/ciaa917

Invasive Disease Potential of Pneumococcal Serotypes in Children After PCV13 Implementation

Clin Infect Dis. 2021 Apr 26;72(8):1453-1456. doi: 10.1093/cid/ciaa917.

Authors

Robert Cohen^{1

2

3

4

5}, Corinne Levy^{1

2

4

5}, Naim Ouldali^{1

2

6}, Marie Goldrey⁷, Stéphane Béchet¹, Stéphane Bonacorsi^{8

9}, Emmanuelle Varon^{2

10}

Affiliations

¹ Association Clinique et Thérapeutique Infantile du Val-de-Marne, Créteil, France.
² Groupe de Pathologie Infectieuse Pédiatrique, Paris, France.
³ Unité Court Séjour, Petits Nourrissons, Service de Néonatalogie, Centre Hospitalier Intercommunal de Créteil, Créteil, France.
⁴ Université Paris Est, IMRB-GRC GEMINI, Créteil, France.
⁵ Clinical Research Center, Centre Hospitalier Intercommunal de Créteil, Créteil, France.
⁶ Unité d'Epidémiologie Clinique, Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, ECEVE INSERM UMR 1123, Paris, France.
⁷ Association Française de Pédiatrie Ambulatoire, Saint-Germain-en-Laye, France.
⁸ Université Paris Diderot, Sorbonne Paris Cité, France.
⁹ Service de Microbiologie, Assistance Publique-Hôpitaux de Paris, Hôpital Robert-Debré, Paris, France.
¹⁰ National Reference Center for Pneumococci, Centre Hospitalier Intercommunal de Créteil, Créteil, France.

PMID: 32804200
DOI: 10.1093/cid/ciaa917

Abstract

We aimed to assess the invasive disease potential of non-PCV13 serotypes after the implementation of this vaccine. Most non-PCV13 serotypes had low invasive disease potential. Among serotypes with the highest invasive disease potential (12F, 24F, 38, 8, 33F, 22F, and 10A), all but 24F and 38 were included in PCV20.

Keywords: 13 valent pneumococcal conjugate vaccine; children; invasive disease potential; pneumococci.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Child
Humans
Infant
Pneumococcal Infections* / epidemiology
Pneumococcal Infections* / prevention & control
Pneumococcal Vaccines
Serogroup
Streptococcus pneumoniae
Vaccines, Conjugate

Substances

Pneumococcal Vaccines
Vaccines, Conjugate