DRD2 C957T genotype modulates the time-on-task effect during total sleep deprivation

Chronobiol Int. 2020 Sep-Oct;37(9-10):1457-1460. doi: 10.1080/07420528.2020.1804925. Epub 2020 Aug 20.

Abstract

Total sleep deprivation (TSD) and time-on-task (TOT), especially in combination, increase cognitive instability and cause performance impairment. There are large inter-individual differences in TSD and TOT effects which, in part, have a genetic basis. Here, we show that the dopamine receptor D2 C957T genetic polymorphism predicts the magnitude of the TOT effect on a psychomotor vigilance test (PVT) during 38 h of TSD. This finding indicates that dopamine availability in the striatum, where the dopamine receptor D2 is most prevalent, influences the TOT effect, suggesting a role for dopaminergic pathways in sustained attention deficits during sleep loss.

Keywords: Sustained attention; cognitive impairment; dopamine; psychomotor vigilance test (PVT); single nucleotide polymorphism; sleep loss; striatum.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Circadian Rhythm*
  • Genotype
  • Humans
  • Psychomotor Performance
  • Reaction Time
  • Receptors, Dopamine D2 / genetics
  • Sleep Deprivation* / genetics
  • Wakefulness

Substances

  • DRD2 protein, human
  • Receptors, Dopamine D2