Unconventional role of lysosomes in phagocytosis

Johannes Westman; Spencer A Freeman; Sergio Grinstein

doi:10.1016/j.ceca.2020.102269

Unconventional role of lysosomes in phagocytosis

Cell Calcium. 2020 Nov:91:102269. doi: 10.1016/j.ceca.2020.102269. Epub 2020 Aug 17.

Authors

Johannes Westman¹, Spencer A Freeman², Sergio Grinstein³

Affiliations

¹ Program in Cell Biology, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, 686 Bay St, Toronto, ON, M5G 0A4, Canada.
² Program in Cell Biology, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, 686 Bay St, Toronto, ON, M5G 0A4, Canada; Department of Biochemistry, University of Toronto, Toronto, ON, M5S 1A8, Canada.
³ Program in Cell Biology, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, 686 Bay St, Toronto, ON, M5G 0A4, Canada; Department of Biochemistry, University of Toronto, Toronto, ON, M5S 1A8, Canada. Electronic address: [email protected].

PMID: 32818767
DOI: 10.1016/j.ceca.2020.102269

Abstract

Lysosomes are generally thought to be required only for the late stages of phagosome maturation, providing the proton pumps (V-ATPases) and hydrolases needed to acidify and degrade the ingested prey. A recent paper by Davis et al. (EMBO J. [2020], doi:10.15252/embj.2019104058) reports the involvement of lysosomes at a much earlier stage, namely in scission of phagosomes from the plasma membrane. Here we analyze these findings, highlighting a number of unexpected observations and unresolved questions.

Keywords: Calcineurin; Calcium; Dynamin; Lysosome; Macrophage; Phagocytosis; TPC; TRPML1.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Calcineurin / metabolism
Calcium / metabolism
Humans
Lysosomes / metabolism*
NADP / analogs & derivatives
NADP / metabolism
Phagocytosis*
Phagosomes / metabolism

Substances

NADP
NAADP
Calcineurin
Calcium

Abstract

Publication types

MeSH terms

Substances

Grants and funding