The Influence of Age and Obesity-Altered Muscle Tissue Composition on Muscular Dimensional Changes: Impact on Strength and Function

J Gerontol A Biol Sci Med Sci. 2020 Nov 13;75(12):2286-2294. doi: 10.1093/gerona/glaa206.

Abstract

The purpose of this study was to determine if muscular dimensional changes with increases in torque production are influenced by age- and obesity-related increases in intramuscular fat, and its relationship to percent body fat (%BF), echo intensity (EI), strength, and maximum walking speed. Sixty-six healthy men were categorized into 3 groups based on age and body mass index status (young normal weight [YNW], older normal weight [ONW], and older obese [OB]). Participants underwent %BF assessments, resting ultrasonography to determine muscle size (cross-sectional area [CSA]) and EI of the superficial quadriceps, and a 10-m maximum walking speed assessment. Maximal and submaximal (rest-100% MVC in 10% increments) isometric leg extension strength was assessed while changes in rectus femoris (RF) CSA, width, and depth were obtained with ultrasonography. Echo intensity and %BF were different among all groups (p ≤ .007), with the YNW and OB groups exhibiting the lowest and highest %BF and EI values, respectively. The RF increased in depth and decreased in width with increases in torque intensity for all groups. The ONW group demonstrated no change (-0.08%) in RF CSA across torque intensities, whereas the YNW group (-11.5%) showed the greatest decrease in CSA, and the OB group showed a more subtle decrease (-4.6%). Among older men, a greater change in RF CSA was related to poorer EI (r = -0.355) and higher %BF (r = -0.346), while a greater decrease in RF width was associated with faster walking speeds (r = -0.431). Examining muscular dimensional changes during contraction is a unique model to investigate the influence of muscle composition on functional performance.

Keywords: Dynapenia; Echo intensity; Sarcopenia; Ultrasonography; Walking speed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Absorptiometry, Photon
  • Adult
  • Aged
  • Body Composition*
  • Humans
  • Image Interpretation, Computer-Assisted
  • Isometric Contraction
  • Male
  • Middle Aged
  • Muscle Strength / physiology*
  • Obesity / physiopathology*
  • Quadriceps Muscle / diagnostic imaging*
  • Quadriceps Muscle / physiopathology*
  • Signal Processing, Computer-Assisted
  • Torque
  • Ultrasonography / methods*
  • Walking Speed