Abstract
Fatty acid binding proteins (FABPs) serve as intracellular chaperones for fatty acids and other hydrophobic ligands inside cells. Recent studies have demonstrated new functions of individual members of the FABP family. This Snapshot describes the overall functions of FABPs in health and disease and highlights emerging roles of adipose FABP (A-FABP) and epidermal FABP (E-FABP) in the fields of obesity, chronic inflammation, and cancer development. To view this SnapShot, open or download the PDF.
Copyright © 2020 Elsevier Inc. All rights reserved.
MeSH terms
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Adipocytes / cytology
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Adipocytes / metabolism
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Fatty Acid-Binding Proteins / metabolism*
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Humans
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Macrophages / cytology
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Macrophages / metabolism
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Models, Biological*
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Neoplasms / metabolism
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Neoplasms / pathology
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Obesity / metabolism
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Obesity / pathology
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Peroxisome Proliferator-Activated Receptors / metabolism
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Signal Transduction
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Skin Diseases / metabolism
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Skin Diseases / pathology
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Sterol Esterase / metabolism
Substances
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FABP4 protein, human
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FABP5 protein, human
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Fatty Acid-Binding Proteins
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Peroxisome Proliferator-Activated Receptors
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Sterol Esterase