A mouse model for SARS-CoV-2 infection by exogenous delivery of hACE2 using alphavirus replicon particles

Cell Res. 2020 Nov;30(11):1046-1048. doi: 10.1038/s41422-020-00405-5. Epub 2020 Aug 25.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Angiotensin-Converting Enzyme 2
  • Animals
  • Betacoronavirus / physiology*
  • COVID-19
  • Cell Line, Transformed
  • Coronavirus Infections / physiopathology*
  • Coronavirus Infections / virology
  • Disease Models, Animal*
  • Encephalitis Virus, Venezuelan Equine / genetics*
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Pandemics
  • Peptidyl-Dipeptidase A / administration & dosage*
  • Peptidyl-Dipeptidase A / genetics
  • Pneumonia, Viral / physiopathology*
  • Pneumonia, Viral / virology
  • Replicon*
  • SARS-CoV-2
  • Transduction, Genetic
  • Virus Replication

Substances

  • Peptidyl-Dipeptidase A
  • Ace2 protein, mouse
  • Angiotensin-Converting Enzyme 2