Plasma Angiotensin Peptide Profiling and ACE (Angiotensin-Converting Enzyme)-2 Activity in COVID-19 Patients Treated With Pharmacological Blockers of the Renin-Angiotensin System

Ulrich Kintscher; Anna Slagman; Oliver Domenig; Robert Röhle; Frank Konietschke; Marko Poglitsch; Martin Möckel

doi:10.1161/HYPERTENSIONAHA.120.15841

Plasma Angiotensin Peptide Profiling and ACE (Angiotensin-Converting Enzyme)-2 Activity in COVID-19 Patients Treated With Pharmacological Blockers of the Renin-Angiotensin System

Hypertension. 2020 Nov;76(5):e34-e36. doi: 10.1161/HYPERTENSIONAHA.120.15841. Epub 2020 Aug 27.

Authors

Ulrich Kintscher^{1

2

3}, Anna Slagman^{1

4}, Oliver Domenig⁵, Robert Röhle^{1

6

7}, Frank Konietschke^{1

8

7}, Marko Poglitsch⁵, Martin Möckel^{1

4}

Affiliations

¹ From the Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Germany (U.K., A.S., M.M., R.R., F.K.).
² Institute of Pharmacology, Center for Cardiovascular Research, Germany (U.K.).
³ DZHK (German Centre for Cardiovascular Research), Partner Site Berlin (U.K.).
⁴ Department of Emergency and Acute Medicine, Campus Mitte and Campus Virchow Clinic (A.S., M.M.).
⁵ Attoquant Diagnostics, Vienna, Austria (O.D., M.P.).
⁶ Institute of Biometry and Clinical Epidemiology, Coordinating Center for Clinical Studies (R.R.).
⁷ Berlin Institute of Health, Germany (R.R., F.K.).
⁸ Institute of Biometry and Clinical Epidemiology (F.K.).

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Angiotensin-Converting Enzyme 2
Angiotensin-Converting Enzyme Inhibitors / administration & dosage*
COVID-19
Cohort Studies
Coronavirus Infections / blood*
Coronavirus Infections / drug therapy*
Female
Germany
Hospitalization / statistics & numerical data
Humans
Intensive Care Units / statistics & numerical data
Male
Middle Aged
Pandemics
Peptidyl-Dipeptidase A / analysis*
Pneumonia, Viral / blood*
Pneumonia, Viral / drug therapy*
Registries*
Renin-Angiotensin System / drug effects*
Retrospective Studies
Risk Assessment
Treatment Outcome

Substances

Angiotensin-Converting Enzyme Inhibitors
Peptidyl-Dipeptidase A
ACE2 protein, human
Angiotensin-Converting Enzyme 2