Unraveling the Mechanism of the Antitumor Activity of Bacillus Calmette-Guérin

Roger Li; Scott M Gilbert; Ashish M Kamat

doi:10.1016/j.eururo.2020.08.027

Unraveling the Mechanism of the Antitumor Activity of Bacillus Calmette-Guérin

Eur Urol. 2021 Jul;80(1):1-3. doi: 10.1016/j.eururo.2020.08.027. Epub 2020 Aug 26.

Authors

Roger Li¹, Scott M Gilbert², Ashish M Kamat³

Affiliations

¹ Department of Genitourinary Oncology, H. Lee Moffitt Cancer Center, Tampa, FL, USA; Department of Immunology, H. Lee Moffitt Cancer Center, Tampa, FL, USA. Electronic address: [email protected].
² Department of Genitourinary Oncology, H. Lee Moffitt Cancer Center, Tampa, FL, USA.
³ Department of Urology, MD Anderson Cancer Center, Houston, TX, USA.

Abstract

Our understanding of the mechanism of bacillus Calmette-Guérin (BCG) in controlling urothelial carcinoma is still evolving. Studies have revealed a complex and multifaceted immune response. BCG-elicited adaptive antitumor immunity directed towards tumor antigens could have major implications for trial design.

Publication types

Editorial

MeSH terms

Adjuvants, Immunologic / therapeutic use
Administration, Intravesical
BCG Vaccine / therapeutic use
Carcinoma, Transitional Cell* / drug therapy
Humans
Urinary Bladder Neoplasms* / drug therapy

Substances

Adjuvants, Immunologic
BCG Vaccine