Case report: a 10-year-old girl with primary hypoparathyroidism and systemic lupus erythematosus

J Pediatr Endocrinol Metab. 2020 Sep 25;33(9):1231-1235. doi: 10.1515/jpem-2020-0015.

Abstract

Objectives Hypoparathyroidism is a rare disease in children that occurs as a result of autoimmune destruction of the parathyroid glands, a defect in parathyroid gland development or secondary to physical parathyroid gland disturbance. Typical symptoms of hypoparathyroidism present as hypocalcaemia and hyperphosphatemia due to decreased parathyroid hormone secretion and may lead to nerve and muscles disturbances resulting in clinical manifestation of tetany, arrhythmias and epilepsy. Currently, there is no conventional hormone replacement treatment for hypoparathyroidism and therapeutic approaches include normalising mineral levels using an oral calcium supplement and active forms of vitamin D. Case presentation We present the case of a 10-year-old girl with primary hypoparathyroidism who had no prior history of autoimmune disorders, but who subsequently developed systemic lupus erythematosus.

Keywords: autoimmune polyglandular syndrome; hyperphosphatemia; hypocalcaemia; parathyroid hormone; primary hypoparathyroidism; systemic lupus erythematosus.

Publication types

  • Case Reports

MeSH terms

  • Calcium / administration & dosage
  • Child
  • Dietary Supplements
  • Female
  • Humans
  • Hypoparathyroidism / complications*
  • Lupus Erythematosus, Systemic / drug therapy
  • Lupus Erythematosus, Systemic / etiology
  • Lupus Erythematosus, Systemic / pathology*
  • Prognosis
  • Vitamin D / administration & dosage
  • Vitamins / administration & dosage

Substances

  • Vitamins
  • Vitamin D
  • Calcium