The purpose of surgically facilitated orthodontic treatment (SFOT) is to increase and thicken the periodontal biotype, including both hard and soft tissue, and facilitate accelerated tooth movement through the induction of the regional acceleratory phenomenon. This article discusses the surgical and biomaterial factors related to increased predictability of bone augmentation when performing this pre-orthodontic surgical technique. Critical surgery-related factors of SFOT that will be examined include incision and flap design and closure, the depth and location of corticotomies, surgical trauma, augmentation protocols, and postoperative considerations. Biomaterial-related factors that will be reviewed encompass bone grafting materials, biologics, barrier membranes, and planned tooth movement.