Association of COVID-19 with skin diseases and relevant biologics: a cross-sectional study using nationwide claim data in South Korea

Br J Dermatol. 2021 Feb;184(2):296-303. doi: 10.1111/bjd.19507. Epub 2020 Oct 13.

Abstract

Background: As the coronavirus disease 2019 (COVID-19) pandemic has spread, information about COVID-19 and skin disease or related biologics is still lacking.

Objectives: To identify the association between COVID-19 and skin diseases or biologics.

Methods: A nationwide claim dataset relevant to COVID-19 in South Korea was analysed. This dataset included insurance claim data before and during COVID-19 treatment and clinical outcomes. Claim data related to skin diseases and relevant biologics were analysed to determine the association of COVID-19 with skin diseases and relevant biologics.

Results: The dataset contained a total of 234 427 individuals (111 947 male and 122 480 female) who underwent COVID-19 testing. Of them, 7590 (3·2%) were confirmed as having COVID-19, and 227 (3·0%) confirmed patients died. Among various skin diseases and biologics, no significant increase in the presence of specific skin diseases or exposure to biologics was observed in the COVID-19-positive group, even after adjusting for or matching covariates. The presence of skin diseases and exposure to biologics also did not seem to affect clinical outcomes including mortality.

Conclusions: Underlying skin diseases did not appear to increase susceptibility to COVID-19 or mortality from COVID-19. Considering the risks and benefits, biologics for dermatological conditions might be continuously used during the COVID-19 pandemic.

MeSH terms

  • Adult
  • Age Factors
  • Aged
  • Biological Products / adverse effects*
  • COVID-19 / diagnosis
  • COVID-19 / epidemiology*
  • COVID-19 / virology
  • COVID-19 Drug Treatment
  • COVID-19 Testing / statistics & numerical data
  • Cross-Sectional Studies
  • Dermatologic Agents / adverse effects*
  • Disease Susceptibility
  • Female
  • Humans
  • Male
  • Middle Aged
  • Pandemics
  • Republic of Korea / epidemiology
  • Risk Factors
  • SARS-CoV-2 / isolation & purification
  • Skin Diseases / drug therapy
  • Skin Diseases / epidemiology*
  • Survival Analysis
  • Young Adult

Substances

  • Biological Products
  • Dermatologic Agents