Neuroimaging in genetic frontotemporal dementia and amyotrophic lateral sclerosis

Suvi Häkkinen; Stephanie A Chu; Suzee E Lee

doi:10.1016/j.nbd.2020.105063

Neuroimaging in genetic frontotemporal dementia and amyotrophic lateral sclerosis

Neurobiol Dis. 2020 Nov:145:105063. doi: 10.1016/j.nbd.2020.105063. Epub 2020 Sep 2.

Authors

Suvi Häkkinen¹, Stephanie A Chu¹, Suzee E Lee²

Affiliations

¹ Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
² Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA. Electronic address: [email protected].

Abstract

Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) have a strong clinical, genetic and pathological overlap. This review focuses on the current understanding of structural, functional and molecular neuroimaging signatures of genetic FTD and ALS. We overview quantitative neuroimaging studies on the most common genes associated with FTD (MAPT, GRN), ALS (SOD1), and both (C9orf72), and summarize visual observations of images reported in the rarer genes (CHMP2B, TARDBP, FUS, OPTN, VCP, UBQLN2, SQSTM1, TREM2, CHCHD10, TBK1).

Keywords: Amyotrophic lateral sclerosis; Frontotemporal dementia; Genetics; Motor neuron disease; Neuroimaging; Presymptomatic.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Amyotrophic Lateral Sclerosis / diagnostic imaging*
Amyotrophic Lateral Sclerosis / genetics
Frontotemporal Dementia / diagnostic imaging*
Frontotemporal Dementia / genetics
Humans
Neuroimaging / methods*

Grants and funding

R01 AG058233/AG/NIA NIH HHS/United States