Lung transplantation during the COVID-19 pandemic: Safely navigating the new "normal"

Am J Transplant. 2020 Nov;20(11):3094-3105. doi: 10.1111/ajt.16304. Epub 2020 Sep 22.

Abstract

In the United States, an overall national decline in organ transplants has accompanied the substantial burden of COVID-19. Amidst significant regional variations in COVID-19, lung transplantation (LTx) remains a critical life-saving operation. Our LTx practice during the early pandemic may provide a blueprint for managing LTx in an era of continued community prevalence. Patients who underwent LTx at our institution between March 1 and May 20, 2020 were included. Recipient, operative, and donor characteristics were compared to those from our program in 2019, and COVID-19 testing practices were evaluated for March, April, and May to understand how our practice adapted to the pandemic. Our program performed 36 LTx, 33% more than the same period in 2019. Recipient, operative, and donor characteristics during COVID-19 were similar to those in 2019. By April 1, all donors and recipients underwent pretransplant COVID-19 testing, all returning negative results. To date, no recipients have developed posttransplant COVID-19. At our institution, pretransplant COVID-19 testing, use of local donor lungs, and avoidance of donors from areas of increased community penetration supported a safe and effective LTx practice during the early COVID-19 pandemic. Continued follow-up is required to ensure the long-term safety of these newly transplanted patients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • COVID-19 / epidemiology*
  • Comorbidity
  • Female
  • Humans
  • Lung Transplantation / methods*
  • Male
  • Middle Aged
  • Pandemics*
  • Retrospective Studies
  • SARS-CoV-2*
  • Tissue Donors / supply & distribution*
  • Transplant Recipients*
  • United States / epidemiology