Enrichment of Rare Variants in Loeys-Dietz Syndrome Genes in Spontaneous Coronary Artery Dissection but Not in Severe Fibromuscular Dysplasia

Affiliations

• ¹ Center of Medical Genetics, University of Antwerp and Antwerp University Hospital, Belgium (A. Verstraeten, M.H.A.M.P., J.A.N.M., L.V.D.H., J.B., E.F., L.V.L., B.L.).
• ² Department of Cardiovascular Sciences and National Institute for Health Research Leicester Biomedical Research Centre, Glenfield Hospital, United Kingdom (A.A.B., T.W., A.A.-H., N.J.S., D.A.).
• ³ Department of Human Genetics (M.K., B.L.), Radboud University Nijmegen Medical Center, The Netherlands.
• ⁴ Department of Clinical Genetics (I.P.C.K.), Maastricht University Medical Centre, The Netherlands.
• ⁵ Department of Cardiology (A.M.), Radboud University Nijmegen Medical Center, The Netherlands.
• ⁶ Maritime Medical Genetics Service, Izaak Walton Killam (IWK) Health Centre, Halifax, Canada (A.R., A. Vandersteen).
• ⁷ Division of Medical Genetics, Department of Pediatrics, Dalhousie University, Halifax, Canada (A. Vandersteen).
• ⁸ Ehlers Danlos Syndrome National Diagnostic Service, Sheffield Clinical Genetics Department, Northern General Hospital, United Kingdom (G.S., D.J.).
• ⁹ StatUa Center for Statistics, University of Antwerp, Belgium (E.F.).
• ¹⁰ Ehlers-Danlos Syndrome, National Diagnostic Service, Northwick Park and St. Mark's Hospitals, Harrow, United Kingdom (N.G., F.S.V.D.).
• ¹¹ Department of Medicine (P.D.L.), Maastricht University Medical Centre, The Netherlands.
• ¹² Division of Cardiology, Centre Hospitalier Universitaire Ambroise Paré, Mons, Belgium (P.D.).
• ¹³ Department of Internal Medicine, European Society of Hypertension Excellence Centre, Centre Hospitalier Universitaire (CHU) Avicenne, assistance publique hôpitaux de paris (AP-HP), Bobigny, France (M.L.-S.).
• ¹⁴ Pole of Cardiovascular Research, Institut de Recherche Expérimentale et Clinique, Division of Cardiology, Cliniques Universitaires Saint-Luc (M.P., A.P.), Université Catholique de Louvain, Brussels, Belgium.
• ¹⁵ Division of Internal Medicine and Hypertension Unit, Department of Medical Sciences, University of Turin, Italy (M.P.).
• ¹⁶ Cardiology Department, University of Liège Hospital, Belgium (M.S.).
• ¹⁷ Sorbonne Université, Université Paris 13, Sorbonne Paris Cité, Institut national de la santé et de la recherche médicale (INSERM), UMR_S 1142, Laboratoire d'Informatique Médicale et d'Ingénieurie des Connaissances en e-Santé (LIMICS), Institut de recherche pour la valorisation des données de santé (IRSAN), France (L.T.).
• ¹⁸ Human Molecular Genetics, de Duve Institute (M.V.), Université Catholique de Louvain, Brussels, Belgium.