Problem-solving in clinical practice: breathing difficulty and muscle weakness following allogeneic haematopoietic stem cell transplantation

Arch Dis Child Educ Pract Ed. 2021 Apr;106(2):125-128. doi: 10.1136/archdischild-2019-317281. Epub 2020 Sep 8.

Abstract

Acute weakness and dyspnoea are unusual presentation after allogeneic haematopoietic stem cell transplantation (HSCT) complicated by chronic graft-versus-host disease (GVHD). The differential diagnosis and management are challenging for the paediatrician. This case chronicles the diagnostic journey of a child who presented with weakness, dyspnoea and difficulty in speech, 2 years after allogeneic HSCT and GVHD and explores the approach to neurological manifestations in this context.

Keywords: bone marrow transplant; graft versus host disease; myasthenia gravis.

Publication types

  • Case Reports

MeSH terms

  • Graft vs Host Disease / diagnosis
  • Graft vs Host Disease / etiology
  • Hematopoietic Stem Cell Transplantation* / adverse effects
  • Humans
  • Muscle Weakness* / diagnosis
  • Muscle Weakness* / etiology