Abstract
Regenerative potential of multipotent mesenchymal stromal cells from the human umbilical cord (MMSC-UC) in the suspension and spheroid form was revealed during the progression of experimental small focal myocardial infarction in rats. In isoproterenol-induced myocardial infarction, foci of necrosis and inflammatory infiltrate and at later terms fibrosis foci were found mainly in the left ventricle of rat heart. In rats receiving MMSC-UC, destructive changes in the myocardium, fibrous scars, and inflammatory process were less pronounced. MMSC-UC also contributed to normalization of the morphofunctional parameters of the heart. Spheroids exhibited higher efficiency in comparison with cell suspension.
Keywords:
isoproterenol; multipotent mesenchymal stromal cells; myocardial infarction; spheroids.
MeSH terms
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Animals
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Disease Models, Animal
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Endomyocardial Fibrosis / chemically induced
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Endomyocardial Fibrosis / pathology
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Endomyocardial Fibrosis / physiopathology
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Endomyocardial Fibrosis / prevention & control*
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Heart Ventricles / pathology
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Heart Ventricles / ultrastructure
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Humans
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Isoproterenol / administration & dosage
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Male
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Mesenchymal Stem Cell Transplantation*
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Mesenchymal Stem Cells / cytology
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Mesenchymal Stem Cells / physiology*
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Myocardial Infarction / chemically induced
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Myocardial Infarction / pathology
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Myocardial Infarction / physiopathology
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Myocardial Infarction / therapy*
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Myocardium / pathology
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Myocardium / ultrastructure
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Myocytes, Cardiac / pathology
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Myocytes, Cardiac / ultrastructure
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Primary Cell Culture
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Rats
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Rats, Wistar
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Regeneration / physiology*
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Spheroids, Cellular / cytology
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Spheroids, Cellular / physiology
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Spheroids, Cellular / transplantation*
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Transplantation, Heterologous
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Treatment Outcome
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Umbilical Cord / cytology
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Umbilical Cord / metabolism