An Mb1-Cre-driven oncogenic Kras mutation results in a mouse model of T-acute lymphoblastic leukemia/lymphoma with short latency and high penetrance

Leukemia. 2021 Jun;35(6):1777-1781. doi: 10.1038/s41375-020-01036-w. Epub 2020 Sep 11.
No abstract available

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Female
  • Integrases / genetics
  • Integrases / metabolism*
  • Male
  • Mice
  • Mutation*
  • Penetrance*
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / genetics
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / metabolism
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / pathology*
  • Proto-Oncogene Proteins p21(ras) / genetics*
  • Transcription Factors / genetics
  • Transcription Factors / metabolism*

Substances

  • KRAS protein, human
  • Transcription Factors
  • Cre recombinase
  • Integrases
  • Proto-Oncogene Proteins p21(ras)