NTCP Deficiency Causes Gallbladder Abnormalities in Mice and Human Beings

Fengfeng Mao; Meng-Xuan Wang; Xinfeng Hou; Zhongmin Zhou; Yan-Yan Yan; Ling-Juan Fang; Zexi Tan; Wei-Yuan Fang; Teng Liu; Wenhui He; Cong Li; Xin-Bao Xie; Shi-Qi Lu; Jianhua Sui; Fengchao Wang; Jun Han; Jian-She Wang; Wenhui Li

doi:10.1016/j.jcmgh.2020.09.001

NTCP Deficiency Causes Gallbladder Abnormalities in Mice and Human Beings

Cell Mol Gastroenterol Hepatol. 2021;11(3):831-839. doi: 10.1016/j.jcmgh.2020.09.001. Epub 2020 Sep 9.

Authors

Fengfeng Mao¹, Meng-Xuan Wang², Xinfeng Hou³, Zhongmin Zhou¹, Yan-Yan Yan⁴, Ling-Juan Fang⁵, Zexi Tan⁶, Wei-Yuan Fang⁴, Teng Liu⁴, Wenhui He⁶, Cong Li³, Xin-Bao Xie⁴, Shi-Qi Lu⁴, Jianhua Sui⁷, Fengchao Wang⁸, Jun Han⁹, Jian-She Wang¹⁰, Wenhui Li¹¹

Affiliations

¹ School of Life Sciences, Beijing Normal University, Beijing, China; National Institute of Biological Sciences, Beijing, China.
² Department of Pediatrics, Jinshan Hospital of Fudan University, Shanghai, China; The Center for Pediatric Liver Diseases, Children's Hospital of Fudan University, Shanghai, China.
³ National Institute of Biological Sciences, Beijing, China; School of Life Sciences, Peking University, Beijing, China.
⁴ The Center for Pediatric Liver Diseases, Children's Hospital of Fudan University, Shanghai, China.
⁵ Department of Pediatric Gastroenterology, the Second Affiliated Hospital, Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
⁶ National Institute of Biological Sciences, Beijing, China.
⁷ School of Life Sciences, Beijing Normal University, Beijing, China; National Institute of Biological Sciences, Beijing, China; Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing, China.
⁸ National Institute of Biological Sciences, Beijing, China; Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing, China.
⁹ University of Victoria-Genome British Columbia Proteomics Centre, University of Victoria, Victoria, British Columbia, Canada; Division of Medical Sciences, University of Victoria, Victoria, British Columbia, Canada.
¹⁰ The Center for Pediatric Liver Diseases, Children's Hospital of Fudan University, Shanghai, China. Electronic address: [email protected].
¹¹ National Institute of Biological Sciences, Beijing, China; Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing, China. Electronic address: [email protected].

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Animals
Cholic Acids / blood*
Cholic Acids / metabolism
Disease Models, Animal
Female
Gallbladder / abnormalities*
Gallbladder / pathology
Gallstones / genetics*
Gallstones / metabolism
Gallstones / pathology
Humans
Infant
Male
Mice
Mice, Knockout
Organic Anion Transporters, Sodium-Dependent / deficiency*
Organic Anion Transporters, Sodium-Dependent / genetics
Polymorphism, Single Nucleotide
Retrospective Studies
Species Specificity
Steroid Metabolism, Inborn Errors / blood
Steroid Metabolism, Inborn Errors / genetics*
Steroid Metabolism, Inborn Errors / metabolism
Steroid Metabolism, Inborn Errors / pathology
Symporters / deficiency*
Symporters / genetics

Substances

Cholic Acids
Organic Anion Transporters, Sodium-Dependent
Symporters
sodium-bile acid cotransporter