Persistent dermal lesions in a patient with previous history of visceral leishmaniasis

Parasitol Int. 2021 Feb:80:102197. doi: 10.1016/j.parint.2020.102197. Epub 2020 Sep 11.

Abstract

Post-kala-azar dermal leishmaniasis (PKDL) is a complication of visceral leishmaniasis (VL) that most frequently occurs after an episode of VL caused by Leishmania donovani. In this case report, we present a 21-year-old male patient with persistent skin lesions and recurrent visceral leishmaniasis (VL) due to Leishmania infantum. The patient did not respond to multiple lines of anti-leishmanial treatment (including Liposomal amphotericin B and miltefosine) and later died from cerebral lesions presumed to be secondary to persistent VL.

Keywords: Cerebral leishmaniasis; Cutaneous leishmaniasis; Leishmania infantum; Postkalaazar dermal leishmanisis (PKDL); Visceral leishmaniasis.

Publication types

  • Case Reports

MeSH terms

  • Albania / ethnology
  • Amphotericin B / therapeutic use*
  • Antiprotozoal Agents / therapeutic use*
  • Fatal Outcome
  • Humans
  • Leishmania infantum / physiology*
  • Leishmaniasis, Visceral / complications
  • Leishmaniasis, Visceral / parasitology
  • Leishmaniasis, Visceral / pathology*
  • Leishmaniasis, Visceral / prevention & control
  • Male
  • Phosphorylcholine / analogs & derivatives*
  • Phosphorylcholine / therapeutic use
  • Recurrence
  • Skin Diseases, Parasitic / parasitology
  • Skin Diseases, Parasitic / pathology*
  • Skin Diseases, Parasitic / prevention & control
  • Turkey
  • Young Adult

Substances

  • Antiprotozoal Agents
  • liposomal amphotericin B
  • Phosphorylcholine
  • miltefosine
  • Amphotericin B