Recording EMT Activity by Lineage Tracing during Metastasis

Pauline Vieugué; Cédric Blanpain

doi:10.1016/j.devcel.2020.07.011

Recording EMT Activity by Lineage Tracing during Metastasis

Dev Cell. 2020 Sep 14;54(5):567-569. doi: 10.1016/j.devcel.2020.07.011.

Authors

Pauline Vieugué¹, Cédric Blanpain²

Affiliations

¹ Laboratory of Stem Cells and Cancer, WELBIO, Université Libre de Bruxelles (ULB), 808 route de Lennik, Bat GE, G2 4.205, 1070 Bruxelles, Belgium.
² Laboratory of Stem Cells and Cancer, WELBIO, Université Libre de Bruxelles (ULB), 808 route de Lennik, Bat GE, G2 4.205, 1070 Bruxelles, Belgium. Electronic address: [email protected].

PMID: 32931747
DOI: 10.1016/j.devcel.2020.07.011

Abstract

In this issue of Developmental Cell, Li et al. develop a novel lineage tracing system to record EMT activity during lung metastasis of mammary tumors. Using EMT-tracer mouse models, they reveal that N-cadherin is transiently expressed by most metastasis-initiating cells and demonstrate its functional importance during the metastatic cascade.

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MeSH terms

Animals
Cadherins / genetics
Cell Differentiation
Epithelial-Mesenchymal Transition
Lung Neoplasms*
Mammary Neoplasms, Animal*
Mice

Substances

Cadherins