Synthesis of Fluoro-, Monofluoromethyl-, Difluoromethyl-, and Trifluoromethyl-Substituted Three-Membered Rings

Jonathan Decaens; Samuel Couve-Bonnaire; André B Charette; Thomas Poisson; Philippe Jubault

doi:10.1002/chem.202003822

Synthesis of Fluoro-, Monofluoromethyl-, Difluoromethyl-, and Trifluoromethyl-Substituted Three-Membered Rings

Chemistry. 2021 Feb 10;27(9):2935-2962. doi: 10.1002/chem.202003822. Epub 2020 Dec 8.

Authors

Jonathan Decaens¹, Samuel Couve-Bonnaire¹, André B Charette², Thomas Poisson^{1

3}, Philippe Jubault¹

Affiliations

¹ INSA Rouen, UNIROUEN, CNRS, COBRA (UMR 6014), Normandie Univ, 76000, Rouen, France.
² Centre in Green Chemistry and Catalysis, Faculty of Arts and Sciences, Department of Chemistry, Université de Montréal, PO Box 6128, Station Downtown, Montréal, Québec, H3C 3J7, Canada.
³ Institut Universitaire de France, 1 rue Descartes, 75231, Paris, France.

PMID: 32939868
DOI: 10.1002/chem.202003822

Abstract

This Minireview describes recent advances toward the synthesis of fluoro-, monofluoromethyl-, difluoromethyl-, and trifluoromethyl-substituted three-membered rings such as cyclopropanes, aziridines, epoxides, episulfides, cyclopropenes, and 2 H-azirines. The main synthetic methodologies since 2016 for cyclopropanes and since 2010 for the other three-membered rings are reported.

Keywords: 3-membered rings; difluoromethyl; fluorine; monofluoromethyl; trifluoromethyl.

Publication types

Review