Abstract
A 61-year-old man with metastatic renal cell carcinoma on cabozantinib developed hand-foot skin reaction with predominantly dorsal involvement including painful violaceous plaques over the joints and keratotic yellow plaques on the palmar fingers. The medication was discontinued with resolution of the plaques and later reinitiated at a lower dose uneventfully.
MeSH terms
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Anilides / adverse effects*
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Anilides / therapeutic use
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Biopsy
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Carcinoma, Renal Cell / drug therapy*
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Foot Dermatoses / chemically induced
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Hand Dermatoses / chemically induced*
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Hand Dermatoses / pathology
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Humans
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Kidney Neoplasms / drug therapy*
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Male
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Middle Aged
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Protein Kinase Inhibitors / adverse effects*
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Protein Kinase Inhibitors / therapeutic use
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Pyridines / adverse effects*
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Pyridines / therapeutic use
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Receptor Protein-Tyrosine Kinases / antagonists & inhibitors
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Skin / pathology
Substances
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Anilides
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Protein Kinase Inhibitors
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Pyridines
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cabozantinib
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Receptor Protein-Tyrosine Kinases