SnapShot: The Regulatory Genome

X Y Bing; P J Batut; M Levo; M Levine; J Raimundo

doi:10.1016/j.cell.2020.07.041

SnapShot: The Regulatory Genome

Cell. 2020 Sep 17;182(6):1674-1674.e1. doi: 10.1016/j.cell.2020.07.041.

Authors

X Y Bing¹, P J Batut¹, M Levo¹, M Levine¹, J Raimundo¹

Affiliation

¹ Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.

Abstract

Enhancers switch genes on and off in response to a variety of intrinsic and external cellular signals. They are the cornerstone of gene regulation and the most pervasive constituents of the regulatory genome. Sequence polymorphisms in enhancer DNAs are a major source of population diversity and predilection to disease. To view this SnapShot, open or download the PDF.

MeSH terms

Animals
Enhancer Elements, Genetic / genetics*
Gene Expression Regulation / genetics*
Heterochromatin / genetics
Heterochromatin / metabolism
Humans
Models, Spatial Interaction
Polycomb-Group Proteins / metabolism

Substances

Heterochromatin
Polycomb-Group Proteins

Grants and funding

R35 GM118147/GM/NIGMS NIH HHS/United States