The lymphatic system in alcohol-associated liver disease

Clin Mol Hepatol. 2020 Oct;26(4):633-638. doi: 10.3350/cmh.2020.0179. Epub 2020 Sep 21.

Abstract

The lymphatic system plays vital roles in interstitial fluid balance and immune cell surveillance. The effect of alcohol on the lymphatic system is poorly understood. This review article explores the role of the lymphatic system in the pathogenesis of alcohol-related disease including alcoholic liver disease (ALD) and the therapeutic potential of targeting hepatic lymphatics for the treatment of ALD.

Keywords: Inflammation; Lymphangiogenesis; Lymphatics; Vascular endothelial growth factor C.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Humans
  • Liver Diseases, Alcoholic*
  • Lymphangiogenesis
  • Lymphatic System
  • Lymphatic Vessels*