The neuroradiological stereotactic examinations provide indispensable information to localize many intracranial lesions: the data obtained by the CT-Scan are complementary of the stereotactic ones. The transfer of the routine CT-Scan transverse axial slices into the Talairach stereotactic system needs a precise definition of the inclination of the plan of the slices and a correct evaluation of the mean magnification factor. The inclination of the slices is appreciated using the bony, vascular and ventricular landmarks clearly identified on the CT-Scan and stereoscopic stereotactic images. We compared the spatial "reconstructed" CT-Scan data with the histopathological findings obtained by serial stereotactic biopsies in 48 tumor patients. The error varied from 1.5 to 4.6% (m: 2.7 +/- 1.2) on the sagittal plane; from 1.3 to 10% (m: 5.8 +/- 3.4) on the transversal plane; from 2.5 to 4.3% (m: 3.5 +/- 0.7) on the axial plane. The mean global error was 3.7% +/- 2.3. The CT-Scan directly performed under stereotactic conditions (acrylic frame) seems to be the more useful procedure. Nevertheless considering the good precision obtained with our methodology applied to the Talairach's system, we consider it suitable when: a) the gantry of the CT-Scan apparatus is too narrow for the acrylic frame; b) the exploitation of previous CT-Scan examinations is necessary; c) patient refuses the discomfort of the acrylic frame.