Combining biopsy tools improves mutation detection rate in central lung cancer

Lars Hagmeyer; Stephan Schäfer; Marianne Engels; Jana Fassunke; Anja Pietzke-Calcagnile; Marcel Treml; Simon-Dominik Herkenrath; Sandhya Matthes; Jürgen Wolf; Reinhard Büttner; Winfried Randerath

doi:10.1183/23120541.00002-2020

Combining biopsy tools improves mutation detection rate in central lung cancer

ERJ Open Res. 2020 Sep 14;6(3):00002-2020. doi: 10.1183/23120541.00002-2020. eCollection 2020 Jul.

Authors

Affiliations

¹ Institute of Pneumology, University of Cologne, Solingen, Germany.
² Hospital Bethanien Solingen, Clinic of Pneumology and Allergology, Center for Sleep Medicine and Respiratory Care, Solingen, Germany.
³ University of Cologne, Institute of Pathology, Cologne, Germany.
⁴ University Hospital of Cologne, Lung Cancer Group Cologne, Department I of Internal Medicine, Cologne, Germany.

Abstract

In central exophytic lung cancer, the detection rate of oncogenic mutations and PDL1 positivity may be increased by combined sampling by forceps and EBUS-TBNA. The additional sampling of mediastinal lymph node and ctDNA may not be of additional benefit. https://bit.ly/2Ve41EF.