Angiogenesis is the core step of wound repair, and vascular endothelial progenitor cells (EPC) play an extremely important role during wound repair. Recent studies have shown that vascular EPC-derived exosomes (EPC-Exo) can protect vessels, promote the proliferation and migration of vascular endothelial cells, and have anti-inflammatory, anti-oxidant and anti-apoptotic effects on vascular endothelial cells. This article reviews the mechanism of vascular EPC-Exo in angiogenesis and its potential applications in wound repair in recent years.
血管新生是创面修复的核心步骤，血管内皮祖细胞(EPC)在其中发挥着极其重要的作用。新近研究显示，血管EPC源性外泌体(EPC-Exo)能保护血管，促进血管内皮细胞增殖、迁移及对血管内皮细胞具有抗炎、抗氧化及抗凋亡等作用。本文就近年来血管EPC-Exo在血管新生的作用机制及创面修复领域的潜在应用研究方面进行综述。.
Keywords: Endothelial progenitor cells; Exosomes; Gene expression; Signal pathway; Wound repair.