The science and medicine of human immunology

Bali Pulendran; Mark M Davis

doi:10.1126/science.aay4014

The science and medicine of human immunology

Science. 2020 Sep 25;369(6511):eaay4014. doi: 10.1126/science.aay4014.

Authors

Bali Pulendran^{1

2

3

4

5}, Mark M Davis^{6

3

5

7}

Affiliations

¹ Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA 94305, USA. [email protected].
² Department of Pathology, Stanford University, Stanford, CA 94305, USA.
³ Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA.
⁴ Stanford ChEM-H: Chemistry, Engineering and Medicine for Human Health, Stanford University, Stanford, CA 94305, USA.
⁵ Stanford University School of Medicine, Stanford, CA 94305, USA.
⁶ Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA 94305, USA.
⁷ Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.

Abstract

Although the development of effective vaccines has saved countless lives from infectious diseases, the basic workings of the human immune system are complex and have required the development of animal models, such as inbred mice, to define mechanisms of immunity. More recently, new strategies and technologies have been developed to directly explore the human immune system with unprecedented precision. We discuss how these approaches are advancing our mechanistic understanding of human immunology and are facilitating the development of vaccines and therapeutics for infection, autoimmune diseases, and cancer.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Autoimmune Diseases / immunology
Autoimmune Diseases / therapy
Communicable Disease Control
Disease Models, Animal
Genetic Variation
Humans
Immune System*
Immunity* / genetics
Immunogenicity, Vaccine* / genetics
Infections / immunology
Infections / therapy
Mice
Mice, Inbred Strains
Neoplasms / immunology
Neoplasms / therapy
Translational Research, Biomedical / trends
Vaccination*
Vaccines / immunology*
Vaccines / therapeutic use*

Substances

Vaccines

Abstract

Publication types

MeSH terms

Substances

Grants and funding