Co-production of MCR-1 and NDM-1 by Escherichia coli sequence type 31 isolated from a newborn in Moscow, Russia

Ofeliia Sulian; Vladimir Ageevets; Irina Lazareva; Vladimir Gostev; Dmitry Popov; Tatiana Vostrikova; Alexander Sukhinin; Yuri Lobzin; Sergey Sidorenko

doi:10.1016/j.ijid.2020.09.1422

Co-production of MCR-1 and NDM-1 by Escherichia coli sequence type 31 isolated from a newborn in Moscow, Russia

Int J Infect Dis. 2020 Dec:101:4-5. doi: 10.1016/j.ijid.2020.09.1422. Epub 2020 Sep 24.

Authors

Ofeliia Sulian¹, Vladimir Ageevets², Irina Lazareva², Vladimir Gostev³, Dmitry Popov⁴, Tatiana Vostrikova⁴, Alexander Sukhinin¹, Yuri Lobzin³, Sergey Sidorenko⁵

Affiliations

¹ Saint Petersburg State Academy of Veterinary Medicine, Saint Petersburg, Russian Federation.
² Paediatric Research and Clinical Centre for Infectious Diseases, Saint Petersburg, Russian Federation.
³ Paediatric Research and Clinical Centre for Infectious Diseases, Saint Petersburg, Russian Federation; North-Western State Medical University "I.I. Mechnikov", Saint Petersburg, Russian Federation.
⁴ A.N. Bakulev National Medical Research Centre for Cardiovascular Surgery, Moscow, Russian Federation.
⁵ Paediatric Research and Clinical Centre for Infectious Diseases, Saint Petersburg, Russian Federation; North-Western State Medical University "I.I. Mechnikov", Saint Petersburg, Russian Federation. Electronic address: [email protected].

PMID: 32979585
DOI: 10.1016/j.ijid.2020.09.1422

Abstract

An Escherichia coli sequence type 31 isolate co-harbouring mcr-1 and bla_NDM-1 genes on the plasmids of Incl2 and IncC groups, respectively, was recovered from a newborn with ventilator-associated pneumonia in Moscow, Russia. The convergence of polymyxin and carbapenem resistance and its expansion beyond Southeast Asia is a serious threat to human health.

Keywords: Carbapenem-resistance; Polymyxin-resistance.

MeSH terms

Anti-Bacterial Agents / therapeutic use
Escherichia coli / genetics
Escherichia coli Infections / metabolism
Escherichia coli Infections / microbiology
Escherichia coli Proteins / biosynthesis*
Escherichia coli Proteins / genetics
Female
Humans
Infant, Newborn
Microbial Sensitivity Tests
Moscow
Plasmids
Pneumonia, Bacterial / microbiology*
beta-Lactamases / biosynthesis*

Substances

Anti-Bacterial Agents
Escherichia coli Proteins
MCR-1 protein, E coli
beta-Lactamases
beta-lactamase NDM-1