Undetectable viral RNA in oocytes from SARS-CoV-2 positive women

M Barragan; J J Guillén; N Martin-Palomino; A Rodriguez; R Vassena

doi:10.1093/humrep/deaa284

Undetectable viral RNA in oocytes from SARS-CoV-2 positive women

Hum Reprod. 2021 Jan 25;36(2):390-394. doi: 10.1093/humrep/deaa284.

Authors

M Barragan¹, J J Guillén¹, N Martin-Palomino¹, A Rodriguez¹, R Vassena¹

Affiliation

¹ Clinica EUGIN, Carrer de Balmes 236, Barcelona 08006, Spain.

Abstract

A central concern for the safe provision of ART during the current coronavirus disease 2019 (COVID-19) pandemic is the possibility of vertical transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection through gametes and preimplantation embryos. Unfortunately, data on SARS-CoV-2 viral presence in oocytes of infected individuals are not available to date. We describe the case of two women who underwent controlled ovarian stimulation and tested positive to SARS-CoV-2 infection by PCR on the day of oocyte collection. The viral RNA for gene N was undetectable in all the oocytes analyzed from the two women.

Keywords: COVID-19; ICSI; IVF; SARS-CoV-2; coronavirus; oocyte; ovarian stimulation.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

COVID-19 Nucleic Acid Testing*
Female
Humans
Oocyte Retrieval
Oocytes / virology*
Ovulation Induction
RNA, Viral / analysis*
SARS-CoV-2 / isolation & purification*

Substances

RNA, Viral