Concanavalin A targeting N-linked glycans in spike proteins influence viral interactions

Hara Jang; Dong-Heon Lee; Hyun Goo Kang; Seung Jae Lee

doi:10.1039/d0dt02932g

Concanavalin A targeting N-linked glycans in spike proteins influence viral interactions

Dalton Trans. 2020 Oct 12;49(39):13538-13543. doi: 10.1039/d0dt02932g.

Authors

Hara Jang¹, Dong-Heon Lee¹, Hyun Goo Kang², Seung Jae Lee³

Affiliations

¹ Department of Chemistry, Jeonbuk National University, Jeonju 54896, Republic of Korea. [email protected].
² Department of Neurology and Biomedical Research Institute, Jeonbuk National University, Jeonju 54896, Republic of Korea.
³ Department of Chemistry, Jeonbuk National University, Jeonju 54896, Republic of Korea. [email protected] and Institute for Molecular Biology and Genetics, Jeonbuk National University, Jeonju 54896, Republic of Korea.

PMID: 33001090
DOI: 10.1039/d0dt02932g

Abstract

Lectins, which exhibit viral-interaction abilities, have garnered attention in the current pandemic era as potential neutralizing agents and vaccine candidates. Viral invasion through envelope proteins is modulated by N-linked glycosylation in the spike (S) protein. This study demonstrates the biophysical aspects between lectins and high-mannose and -galactose N-glycans to provide insights into binding events.

MeSH terms

Antiviral Agents / pharmacology*
Concanavalin A / pharmacology*
Coronavirus / drug effects
Coronavirus / physiology
Coronavirus Infections / drug therapy
HIV Infections / drug therapy
HIV-1 / drug effects
HIV-1 / physiology
Host-Pathogen Interactions / drug effects
Humans
Mannose / metabolism
Polysaccharides / metabolism*
Spike Glycoprotein, Coronavirus / metabolism
Viral Envelope Proteins / metabolism*

Substances

Antiviral Agents
Polysaccharides
Spike Glycoprotein, Coronavirus
Viral Envelope Proteins
Concanavalin A
Mannose