The Hippo Show Must Go On: YAP Activation as a Therapeutic Strategy in Colorectal Cancer

Veronica Veschi; Giorgio Stassi

doi:10.1016/j.stem.2020.09.007

The Hippo Show Must Go On: YAP Activation as a Therapeutic Strategy in Colorectal Cancer

Cell Stem Cell. 2020 Oct 1;27(4):501-502. doi: 10.1016/j.stem.2020.09.007.

Authors

Veronica Veschi¹, Giorgio Stassi²

Affiliations

¹ Department of Surgical, Oncological and Stomatological Sciences (DICHIRONS), University of Palermo, 90127 Palermo, Italy.
² Department of Surgical, Oncological and Stomatological Sciences (DICHIRONS), University of Palermo, 90127 Palermo, Italy. Electronic address: [email protected].

PMID: 33007230
DOI: 10.1016/j.stem.2020.09.007

Abstract

The role of Hippo pathway in colorectal cancer (CRC) initiation and progression has been controversial. In this issue of Cell Stem Cell, Cheung et al. (2020) shed new light on a distinct function of the transcriptional co-activator YAP as a tumor suppressor and Wnt pathway inhibitor in CRC.

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MeSH terms

Colorectal Neoplasms* / drug therapy
Hippo Signaling Pathway
Humans
Protein Serine-Threonine Kinases* / metabolism
Stem Cells / metabolism
Transcription Factors
Wnt Signaling Pathway

Substances

Transcription Factors
Protein Serine-Threonine Kinases