Abstract
The Veneto region is one of the most affected Italian regions by COVID-19. Chronic lung diseases, such as chronic obstructive pulmonary disease (COPD), may constitute a risk factor in COVID-19. Moreover, respiratory viruses were generally associated with severe pulmonary impairment in cystic fibrosis (CF). We would have therefore expected numerous cases of severe COVID-19 among the CF population. Surprisingly, we found that CF patients were significantly protected against infection by SARS-CoV-2. We discussed this aspect formulating some reasonable theories.
Keywords:
Azythromycin; Covid-19; Cystic fibrosis; DNase; SARS-CoV-2.
MeSH terms
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Adult
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COVID-19
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COVID-19 Testing
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Clinical Laboratory Techniques / methods
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Cohort Studies
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Coronavirus Infections / diagnosis
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Coronavirus Infections / epidemiology*
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Coronavirus Infections / prevention & control
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Cystic Fibrosis / diagnosis
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Cystic Fibrosis / epidemiology*
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Female
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Humans
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Incidence
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Italy / epidemiology
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Male
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Middle Aged
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Pandemics / prevention & control
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Pandemics / statistics & numerical data*
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Pneumonia, Viral / epidemiology*
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Pneumonia, Viral / prevention & control
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Pulmonary Disease, Chronic Obstructive / diagnosis
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Pulmonary Disease, Chronic Obstructive / epidemiology*
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Real-Time Polymerase Chain Reaction / methods
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Reference Values
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Retrospective Studies
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Risk Assessment