Salvianolic acid C potently inhibits SARS-CoV-2 infection by blocking the formation of six-helix bundle core of spike protein

Signal Transduct Target Ther. 2020 Oct 6;5(1):220. doi: 10.1038/s41392-020-00325-1.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkenes / chemistry
  • Alkenes / pharmacology*
  • Angiotensin-Converting Enzyme 2
  • Animals
  • Antiviral Agents / chemistry
  • Antiviral Agents / pharmacology*
  • Betacoronavirus / drug effects*
  • Betacoronavirus / genetics
  • Betacoronavirus / growth & development
  • Betacoronavirus / metabolism
  • Binding Sites
  • Biological Assay
  • COVID-19
  • Chlorocebus aethiops
  • Coronavirus Infections / drug therapy
  • Drug Discovery
  • Gene Expression
  • HEK293 Cells
  • Humans
  • Inhibitory Concentration 50
  • Molecular Docking Simulation
  • Pandemics
  • Peptidyl-Dipeptidase A / chemistry
  • Peptidyl-Dipeptidase A / genetics
  • Peptidyl-Dipeptidase A / metabolism
  • Pneumonia, Viral / drug therapy
  • Polyphenols / chemistry
  • Polyphenols / pharmacology*
  • Protein Binding
  • Protein Conformation, alpha-Helical
  • Protein Interaction Domains and Motifs
  • Protein Subunits / antagonists & inhibitors*
  • Protein Subunits / chemistry
  • Protein Subunits / genetics
  • Protein Subunits / metabolism
  • Receptors, Virus / chemistry
  • Receptors, Virus / genetics
  • Receptors, Virus / metabolism
  • SARS-CoV-2
  • Spike Glycoprotein, Coronavirus / antagonists & inhibitors*
  • Spike Glycoprotein, Coronavirus / chemistry
  • Spike Glycoprotein, Coronavirus / genetics
  • Spike Glycoprotein, Coronavirus / metabolism
  • Vero Cells
  • Virus Internalization / drug effects*

Substances

  • Alkenes
  • Antiviral Agents
  • Polyphenols
  • Protein Subunits
  • Receptors, Virus
  • Spike Glycoprotein, Coronavirus
  • spike protein, SARS-CoV-2
  • Peptidyl-Dipeptidase A
  • ACE2 protein, human
  • Angiotensin-Converting Enzyme 2
  • salvianolic acid C