Corneo-limbo-conjunctival transposition to treat deep and perforating corneal ulcers in dogs: A review of 418 eyes and corneal clarity scoring in 111 eyes

Vet Ophthalmol. 2021 Jan;24(1):48-58. doi: 10.1111/vop.12833. Epub 2020 Oct 9.

Abstract

Purpose: To report surgical and corneal clarity scores (CCSs) of corneo-limbo-conjunctival transpositions (CLCTs) in a large number of canine cases.

Methods: Retrospective review of records that underwent CLCT to repair deep ulcers or perforations between 2002 and 2018. Signalment, concurrent eye disease, additional procedures, pathogenesis, medication, graft orientation, follow-up, and CCSs were recorded.

Results: 418 eyes of 399 dogs were included. Brachycephalics were most commonly affected, comprising 325/418 (77.75%) of the eyes. The most commonly affected breeds were Pugs, Shih Tzus, Cavalier King Charles Spaniels, and French Bulldogs, with 116/418 (27.75%), 64/418 (15.31%), 34/418 (8.13%), and 34/418 (8.13%) ulcerated eyes, respectively. Mean age at surgery was 5.5 years (range 59 days-17.7 years), and median follow-up time was 100 days (range 3 days-7.64 years). The most common etiopathogenesis was spontaneous ulceration in 205/418 eyes (49.04%) of which 191 (93.17%) occurred in brachycephalics. Primary keratoconjunctivitis sicca affected 122/418 eyes (29.19%) and injury 39/418 eyes (9.33%). Mean ulcer width was 3.5 mm (0.5-10 mm). Success rate was 97.13% (406/418 eyes). Failure end points recorded included no menace response, secondary glaucoma, and endophthalmitis. Pre-existing perforation was found in 101/418 (24.16%) of the eyes and significantly increased failure rate (P < .001). The median CCS was G3 (G0-G4), which was lower for Pugs (G2). Graft orientation affected CCS, but did not reach statistical significance.

Conclusion: The high success rate and CCS for CLCT in dogs make it a good technique to treat deep ulcers but a less desirable outcome is anticipated when treating perforations and Pugs.

Keywords: canine; corneal grafting; corneal reconstruction; corneal surgery; corneal transparency.

MeSH terms

  • Animals
  • Conjunctiva / surgery
  • Conjunctiva / transplantation
  • Cornea / surgery
  • Corneal Transplantation / methods
  • Corneal Transplantation / veterinary*
  • Corneal Ulcer / surgery
  • Corneal Ulcer / veterinary*
  • Dog Diseases / surgery*
  • Dogs
  • Female
  • Limbus Corneae / surgery
  • Male
  • Ophthalmologic Surgical Procedures / methods
  • Ophthalmologic Surgical Procedures / veterinary*
  • Postoperative Care / veterinary
  • Retrospective Studies
  • Treatment Outcome