We inoculated 6 cattle with severe acute respiratory syndrome coronavirus 2 and kept them together with 3 uninoculated cattle. We observed viral replication and specific seroreactivity in 2 inoculated animals, despite high levels of preexisting antibody titers against a bovine betacoronavirus. The in-contact animals did not become infected.
Keywords: Bos taurus; COVID-19; SARS-CoV-2; cattle; coronavirus; coronavirus disease; experimental infection; respiratory infections; serology; severe acute respiratory syndrome coronavirus 2; viruses; zoonoses.