Meningeal Relapse of Nodular Lymphocyte Predominant Hodgkin Lymphoma Transformed to T-Cell/Histiocyte-Rich Large B-Cell Lymphoma: A Case Report

Paolo Salvioni Chiabotti; Bettina Bisig; Anne Cairoli; Steven D Hajdu; Pierre-Yves Lovey; Dina Milowich; Sonia Ziadi; Renaud Du Pasquier; Jean-Philippe Brouland; Laurence de Leval

doi:10.3389/fonc.2020.01745

Meningeal Relapse of Nodular Lymphocyte Predominant Hodgkin Lymphoma Transformed to T-Cell/Histiocyte-Rich Large B-Cell Lymphoma: A Case Report

Front Oncol. 2020 Sep 14:10:1745. doi: 10.3389/fonc.2020.01745. eCollection 2020.

Affiliations

¹ Department of Clinical Neurosciences, CHUV University Hospital and University of Lausanne, Lausanne, Switzerland.
² Department of Laboratory Medicine and Pathology, Institute of Pathology, CHUV University Hospital and University of Lausanne, Lausanne, Switzerland.
³ Department of Oncology, CHUV University Hospital and University of Lausanne, Lausanne, Switzerland.
⁴ Department of Diagnostic and Interventional Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
⁵ Department of Medicine, Service of Hematology, Sion, Switzerland.

Abstract

Central nervous system involvement in Hodgkin lymphoma is extremely rare, especially in nodular lymphocyte predominant Hodgkin lymphoma (NLPHL), which usually carries a favorable prognosis. Here we report a case of a young patient with NLPHL, who developed a progressive and fatal neurological deterioration requiring a very extensive work-up including two biopsies to obtain the diagnosis of T-cell/histiocyte-rich large B-cell lymphoma like transformation. This report, which includes post-mortem analysis, highlights the correlations between clinical, radiological, and biological data but also the difficulties encountered in reaching the correct diagnosis.

Keywords: Central nervous system; T-cell/histiocyte-rich Large B-cell lymphoma; autopsy; case report; cerebrospinal fluid; nodular lymphocyte predominant Hodgkin lymphoma; transformation.

Publication types

Case Reports