Murine Typhus Outbreak Presenting as Multisystem Inflammatory Syndrome in Children During SARS-CoV-2 Pandemic

Pediatr Infect Dis J. 2020 Dec;39(12):e447-e449. doi: 10.1097/INF.0000000000002947.

Abstract

Multisystem inflammatory syndrome in children is a severe illness associated with the SARS-CoV-2 pandemic that possesses features overlapping with other pediatric diseases causing systemic inflammation. Significant diagnostic and treatment uncertainty remain, and clinicians should maintain a broad differential when evaluating patients for multisystem inflammatory syndrome in children, as antibiotic-susceptible infections such as murine typhus may present similarly.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Animals
  • Biomarkers
  • COVID-19 / complications*
  • COVID-19 / diagnosis
  • COVID-19 / epidemiology
  • COVID-19 / etiology
  • Child
  • Disease Outbreaks*
  • Humans
  • Mice
  • Pandemics
  • Symptom Assessment
  • Systemic Inflammatory Response Syndrome / diagnosis*
  • Systemic Inflammatory Response Syndrome / epidemiology
  • Systemic Inflammatory Response Syndrome / etiology
  • Typhus, Endemic Flea-Borne / diagnosis*
  • Typhus, Endemic Flea-Borne / epidemiology*
  • Typhus, Endemic Flea-Borne / etiology
  • Typhus, Endemic Flea-Borne / transmission

Substances

  • Biomarkers

Supplementary concepts

  • pediatric multisystem inflammatory disease, COVID-19 related