Isolated cerebral mucormycosis associated with intravenous drug use

J Mycol Med. 2020 Dec;30(4):101046. doi: 10.1016/j.mycmed.2020.101046. Epub 2020 Oct 6.

Abstract

We present an uncommon case of isolated basal ganglia mucormycosis in a patient without any known cause of immunosuppression, but with a history of drug injection. The patient presented a good clinical and radiological response to antifungal treatment without aggressive surgical debridement (liposomal amphotericin B combined with isavuconazole for 4 weeks followed by isavuconazole as maintenance therapy for 10 months).

Keywords: Basal ganglia; Isavuconazole; Mucormycosis.

Publication types

  • Case Reports

MeSH terms

  • Amphotericin B / administration & dosage
  • Central Nervous System Fungal Infections / diagnosis
  • Central Nervous System Fungal Infections / drug therapy
  • Central Nervous System Fungal Infections / etiology*
  • Central Nervous System Fungal Infections / microbiology
  • Cocaine
  • Cocaine-Related Disorders / complications
  • Cocaine-Related Disorders / drug therapy
  • Cocaine-Related Disorders / microbiology
  • Drug Therapy, Combination
  • Drug Users
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Marijuana Abuse / complications
  • Marijuana Abuse / drug therapy
  • Marijuana Abuse / microbiology
  • Middle Aged
  • Mucormycosis / diagnosis
  • Mucormycosis / drug therapy
  • Mucormycosis / etiology*
  • Mucormycosis / microbiology
  • Nitriles / administration & dosage
  • Pyridines / administration & dosage
  • Substance Abuse, Intravenous / complications*
  • Substance Abuse, Intravenous / diagnostic imaging
  • Substance Abuse, Intravenous / drug therapy
  • Substance Abuse, Intravenous / microbiology*
  • Triazoles / administration & dosage

Substances

  • Nitriles
  • Pyridines
  • Triazoles
  • liposomal amphotericin B
  • isavuconazole
  • Amphotericin B
  • Cocaine