Reactive Eccrine Syringofibroadenomatosis Associated With Venous Leg Ulcers: A Case Report and Literature Review

Int J Low Extrem Wounds. 2023 Mar;22(1):135-138. doi: 10.1177/1534734620966900. Epub 2020 Oct 20.

Abstract

Eccrine syringofibroadenoma (ESFA) is a rare adnexal tumor deriving from the acrosyringeal portion of the eccrine duct. Five subtypes of ESFA were described including a reactive form. Reactive ESFAs are associated with inflammatory and neoplastic dermatoses. In this article, we report the case of a 90-year-old woman presenting with 3 leg ulcers evolving for 2 years surrounded by large verrucous and eczematous lesions. Multiple skin biopsies showed anastomosing epithelial cords connected to the epidermis consistent with ESFA. We identified 8 cases of ESFA associated with chronic leg ulcers in the literature and reviewed their main clinical and histological features.

Keywords: adnexal tumor; eccrine syringofibroadenomatosis; venous leg ulcers.

Publication types

  • Review
  • Case Reports

MeSH terms

  • Adenoma, Sweat Gland* / complications
  • Adenoma, Sweat Gland* / pathology
  • Aged, 80 and over
  • Eccrine Glands / pathology
  • Female
  • Humans
  • Leg Ulcer* / pathology
  • Skin / pathology
  • Skin Neoplasms* / complications
  • Skin Neoplasms* / diagnosis
  • Skin Neoplasms* / pathology
  • Sweat Gland Neoplasms* / complications
  • Sweat Gland Neoplasms* / diagnosis
  • Sweat Gland Neoplasms* / pathology
  • Varicose Ulcer* / pathology