The ubiquitin ligase E6AP facilitates HDAC6-mediated deacetylation and degradation of tumor suppressors

Signal Transduct Target Ther. 2020 Oct 19;5(1):243. doi: 10.1038/s41392-020-00330-4.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylation
  • Hep G2 Cells
  • Histone Deacetylase 6 / genetics
  • Histone Deacetylase 6 / metabolism*
  • Humans
  • Proteolysis*
  • Tumor Suppressor Proteins / genetics
  • Tumor Suppressor Proteins / metabolism*
  • Ubiquitin-Protein Ligases / genetics
  • Ubiquitin-Protein Ligases / metabolism*

Substances

  • Tumor Suppressor Proteins
  • UBE3A protein, human
  • Ubiquitin-Protein Ligases
  • HDAC6 protein, human
  • Histone Deacetylase 6