Salmonella enterica serovar Typhi H58, an antimicrobial-resistant lineage, is globally disseminated but has not been reported in Latin America. Genomic analysis revealed 3 independent introductions of Salmonella Typhi H58 with reduced fluoroquinolone susceptibility into Chile. Our findings highlight the utility of enhanced genomic surveillance for typhoid fever in this region.
Keywords: Chile; Salmonella Typhi H58; South America; antimicrobial resistance; bacteria; enteric diseases; fluoroquinolone resistance; genotyping; whole-genome sequencing.