Abstract
Twenty-one evaluable patients with metastatic colorectal carcinoma were treated with a combination of continuous-infusion cisplatin (25 mg/m2/day X 3 days) and bolus 5-fluorouracil (400 mg/m2/day X 3 days). Toxicity was minimal. Seven patients (33%) responded. All responses were observed among the 16 previously untreated patients (44%) and lasted a median of 30 weeks. The results indicate the need for phase III trials of this treatment.
Publication types
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Clinical Trial
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Aged
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Antineoplastic Combined Chemotherapy Protocols / adverse effects
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
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Cisplatin / administration & dosage
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Clinical Trials as Topic
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Colonic Neoplasms / drug therapy*
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Colonic Neoplasms / pathology
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Drug Evaluation
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Fluorouracil / administration & dosage
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Humans
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Middle Aged
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Rectal Neoplasms / drug therapy*
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Rectal Neoplasms / pathology